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TargetC5a anaphylatoxin chemotactic receptor 1
LigandBDBM50192041
Substrate/Competitorn/a
Meas. Tech.ChEMBL_394610 (CHEMBL910269)
IC50 39±n/a nM
Citation Schnatbaum, KLocardi, EScharn, DRichter, UHawlisch, HKnolle, JPolakowski, T Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett16:5088-92 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C5a anaphylatoxin chemotactic receptor 1
Name:C5a anaphylatoxin chemotactic receptor 1
Synonyms:C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:Enzyme
Mol. Mass.:39347.68
Organism:Homo sapiens (Human)
Description:P21730
Residue:350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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  Blast E-value cutoff:
BDBM50192041
n/a
NameBDBM50192041
Synonyms:CHEMBL2371928 | Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2
TypeSmall organic molecule
Emp. Form.C49H63FN10O9
Mol. Mass.955.0845
SMILESCC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Structure
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