Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | C5a anaphylatoxin chemotactic receptor 1 | ||
Ligand | BDBM50192046 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_394610 (CHEMBL910269) | ||
IC50 | 360±n/a nM | ||
Citation | Schnatbaum, K; Locardi, E; Scharn, D; Richter, U; Hawlisch, H; Knolle, J; Polakowski, T Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett16:5088-92 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
C5a anaphylatoxin chemotactic receptor 1 | |||
Name: | C5a anaphylatoxin chemotactic receptor 1 | ||
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 | ||
Type: | Enzyme | ||
Mol. Mass.: | 39347.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21730 | ||
Residue: | 350 | ||
Sequence: |
| ||
BDBM50192046 | |||
n/a | |||
Name | BDBM50192046 | ||
Synonyms: | Ac-Phe-[Orn-Pro-cha-Trp-Har] | CHEMBL415150 | ||
Type | Small organic molecule | ||
Emp. Form. | C48H67N11O7 | ||
Mol. Mass. | 910.1151 | ||
SMILES | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCNC(=O)[C@H](CCCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C1=O |wU:59.67,34.35,22.23,4.3,wD:48.51,15.15,(-3.46,-34.69,;-2.69,-33.36,;-3.46,-32.02,;-1.17,-33.36,;-.4,-32.02,;-1.17,-30.69,;-.4,-29.36,;1.14,-29.36,;1.92,-28.03,;1.14,-26.69,;-.41,-26.7,;-1.16,-28.04,;1.14,-32.02,;1.91,-33.35,;1.91,-30.69,;3.45,-30.69,;5.11,-31.8,;4.49,-33.54,;5.67,-34.52,;7.27,-33.56,;8.66,-35.05,;8.92,-36.57,;10.1,-34.52,;10.87,-35.86,;10.1,-37.2,;10.87,-38.53,;10.1,-39.86,;10.87,-41.19,;12.41,-41.19,;13.18,-42.53,;13.18,-39.86,;10.48,-32.68,;12.05,-32.21,;13.49,-32.72,;12.31,-30.69,;13.85,-30.69,;14.62,-29.36,;14,-27.95,;15.14,-26.92,;16.48,-27.69,;17.94,-27.21,;19.09,-28.25,;18.76,-29.75,;17.3,-30.22,;16.15,-29.19,;10.76,-29.48,;11.28,-27.84,;12.46,-26.85,;10.1,-26.85,;10.87,-25.52,;10.1,-24.19,;10.87,-22.85,;10.1,-21.52,;8.56,-21.52,;7.79,-22.85,;8.56,-24.19,;8.54,-27.32,;7.12,-26.33,;6.85,-24.8,;5.67,-26.85,;4.32,-26.07,;3.4,-27.2,;3.87,-28.66,;5.41,-28.66,;3.72,-29.17,;2.28,-28.65,)| | ||
Structure |