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TargetOxysterols receptor LXR-beta
LigandBDBM50192148
Substrate/Competitorn/a
Meas. Tech.ChEMBL_406040 (CHEMBL912144)
IC50 2±n/a nM
Citation Panday, NBenz, JBlum-Kaelin, DBourgeaux, VDehmlow, HHartman, PKuhn, BRatni, HWarot, XWright, MB Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta. Bioorg Med Chem Lett16:5231-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Oxysterols receptor LXR-beta
Name:Oxysterols receptor LXR-beta
Synonyms:LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:50978.79
Organism:Homo sapiens (Human)
Description:P55055
Residue:460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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  Blast E-value cutoff:
BDBM50192148
n/a
NameBDBM50192148
Synonyms:2-(3-chloro-4-(ethyl(thiazol-4-ylmethyl)amino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | CHEMBL215036
TypeSmall organic molecule
Emp. Form.C15H13ClF6N2OS
Mol. Mass.418.785
SMILESCCN(Cc1cscn1)c1ccc(cc1Cl)C(O)(C(F)(F)F)C(F)(F)F
Structure
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