Ki Summary

Reaction Details

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Target

Wee1-like protein kinase

Ligand

BDBM50192424

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_379935 (CHEMBL864855)

IC50

49±n/a nM

Citation

Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem49:4896-911 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Wee1-like protein kinase

Name:

Wee1-like protein kinase

Synonyms:

Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN

Type:

PROTEIN

Mol. Mass.:

71599.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1445054

Residue:

646

Sequence:

MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY

BDBM50192424

n/a

Name

BDBM50192424

Synonyms:

4-(2,6-dichloro-4-hydroxyphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL379392

Type

Small organic molecule

Emp. Form.

C20H10Cl2N2O4

Mol. Mass.

413.21

SMILES

Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cc(O)cc1Cl |(7.99,-23.45,;9.33,-24.22,;9.32,-25.76,;10.66,-26.53,;11.99,-25.76,;13.46,-26.24,;14.37,-24.99,;15.91,-24.83,;16.54,-23.42,;15.62,-22.17,;15.94,-20.66,;17.35,-20.04,;14.61,-19.89,;13.47,-20.92,;11.96,-20.6,;14.09,-22.32,;13.46,-23.73,;11.99,-24.21,;10.65,-23.45,;18.06,-23.25,;18.68,-21.85,;17.77,-20.61,;20.21,-21.68,;21.12,-22.92,;22.65,-22.76,;20.5,-24.33,;18.97,-24.5,;18.35,-25.9,)|

Structure