Reaction Details |
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Target | Wee1-like protein kinase |
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Ligand | BDBM50192437 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_379935 (CHEMBL864855) |
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IC50 | 28±n/a nM |
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Citation | Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem49:4896-911 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Wee1-like protein kinase |
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Name: | Wee1-like protein kinase |
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 71599.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1445054 |
Residue: | 646 |
Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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BDBM50192437 |
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n/a |
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Name | BDBM50192437 |
Synonyms: | 4-(2,3-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL384477 |
Type | Small organic molecule |
Emp. Form. | C20H10Cl2N2O3 |
Mol. Mass. | 397.211 |
SMILES | Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1cccc(Cl)c1Cl |
Structure |
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