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TargetWee1-like protein kinase
LigandBDBM50192379
Substrate/Competitorn/a
Meas. Tech.ChEMBL_379935 (CHEMBL864855)
IC50 75±n/a nM
Citation Palmer, BDThompson, AMBooth, RJDobrusin, EMKraker, AJLee, HHLunney, EAMitchell, LHOrtwine, DFSmaill, JBSwan, LMDenny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem49:4896-911 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Wee1-like protein kinase
Name:Wee1-like protein kinase
Synonyms:Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:PROTEIN
Mol. Mass.:71599.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1445054
Residue:646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50192379
n/a
NameBDBM50192379
Synonyms:4-(2,6-dimethylphenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL385194
TypeSmall organic molecule
Emp. Form.C22H16N2O3
Mol. Mass.356.374
SMILESCc1cccc(C)c1-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 |(19.86,-2.13,;20.49,-.72,;22.02,-.56,;22.64,.85,;21.72,2.1,;20.2,1.93,;19.29,3.17,;19.58,.52,;18.06,.36,;17.42,-1.06,;15.89,-1.21,;14.98,-2.47,;13.5,-1.99,;12.17,-2.76,;10.84,-1.99,;10.84,-.44,;9.51,.33,;12.17,.33,;13.5,-.44,;14.98,.04,;15.61,1.45,;14.98,2.86,;13.48,3.18,;16.13,3.88,;17.46,3.11,;18.86,3.73,;17.13,1.61,)|
Structure
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