| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase |
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| Ligand | BDBM50192428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_379935 (CHEMBL864855) |
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| IC50 | 42±n/a nM |
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| Citation |  Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem49:4896-911 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase |
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| Name: | Wee1-like protein kinase |
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| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71599.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445054 |
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| Residue: | 646 |
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| Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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| BDBM50192428 |
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| n/a |
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| Name | BDBM50192428 |
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| Synonyms: | 9-hydroxy-4-(3-thienyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | 9-hydroxy-4-(thiophen-3-yl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL377839 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H10N2O3S |
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| Mol. Mass. | 334.349 |
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| SMILES | Oc1ccc2[nH]c3cc(-c4ccsc4)c4C(=O)NC(=O)c4c3c2c1 |
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| Structure | 
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