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TargetVitamin K-dependent protein C
LigandBDBM50193234
Substrate/Competitorn/a
Meas. Tech.ChEMBL_381887
IC50 100±n/a nM
Citation De Nanteuil GGloanec PBéguin SGiesen PLHemker HCMennecier PRupin AVerbeuren TJ Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. J Med Chem 49:5047-50 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vitamin K-dependent protein C
Name:Vitamin K-dependent protein C
Synonyms:Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor
Type:Enzyme
Mol. Mass.:52067.73
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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  Blast E-value cutoff:
BDBM50193234
n/a
NameBDBM50193234
Synonyms:CHEMBL211973 | {(R)-1-[2-(4-carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-2-cyclohexyl-ethylamino}-acetic acid
TypeSmall organic molecule
Emp. Form.C29H37N5O4
Mol. Mass.519.6352
SMILESNC(=N)c1ccc(CNC(=O)C2(Cc3ccccc3C2)NC(=O)[C@@H](CC2CCCCC2)NCC(O)=O)cc1
Structure
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