| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocyte-stimulating hormone receptor |
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| Ligand | BDBM50193836 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422335 (CHEMBL908720) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Cain, JP; Mayorov, AV; Cai, M; Wang, H; Tan, B; Chandler, K; Lee, Y; Petrov, RR; Trivedi, D; Hruby, VJ Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorg Med Chem Lett16:5462-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocyte-stimulating hormone receptor |
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| Name: | Melanocyte-stimulating hormone receptor |
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| Synonyms: | MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 34717.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01726 |
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| Residue: | 317 |
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| Sequence: | MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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| BDBM50193836 |
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| n/a |
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| Name | BDBM50193836 |
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| Synonyms: | 1-((3R,8aS)-3-benzyl-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-phenylethanone | CHEMBL373821 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O |
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| Mol. Mass. | 334.4546 |
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| SMILES | O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1 |
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| Structure | 
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