Ki Summary

Reaction Details

Report a problem with these data

Target

Melanocortin receptor 5

Ligand

BDBM50193833

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_422338 (CHEMBL908723)

IC50

0.100000±n/a nM

Citation

Cain, JP; Mayorov, AV; Cai, M; Wang, H; Tan, B; Chandler, K; Lee, Y; Petrov, RR; Trivedi, D; Hruby, VJ Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorg Med Chem Lett16:5462-7 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 5

Name:

Melanocortin receptor 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

36612.92

Organism:

Homo sapiens (Human)

Description:

P33032

Residue:

325

Sequence:

MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD

BDBM50193833

n/a

Name

BDBM50193833

Synonyms:

CHEMBL220018 | N-[(S)-1-((3S,8aS)-3-benzyl-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-4-guanidino-butyl]-3-(1H-indol-3-yl)-propionamide

Type

Small organic molecule

Emp. Form.

C31H41N7O2

Mol. Mass.

543.7029

SMILES

NC(N)=NCCC[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 |wU:7.7,32.36,26.32,(10.03,-44.77,;8.72,-43.97,;7.37,-44.71,;8.75,-42.43,;7.43,-41.63,;7.46,-40.09,;6.15,-39.29,;6.18,-37.75,;7.51,-36.98,;8.84,-37.75,;8.85,-39.29,;10.18,-36.98,;11.51,-37.74,;12.84,-36.97,;13,-35.46,;14.5,-35.13,;15.28,-36.46,;16.77,-36.78,;17.25,-38.23,;16.22,-39.38,;14.72,-39.06,;14.25,-37.6,;4.88,-36.93,;4.85,-35.42,;3.51,-37.64,;2.21,-36.81,;.85,-37.54,;-.6,-37,;-1.56,-38.23,;-.68,-39.48,;.79,-39.07,;2.09,-39.88,;3.57,-39.24,;4.87,-40.06,;4.89,-41.6,;3.56,-42.38,;3.58,-43.92,;4.93,-44.67,;6.26,-43.87,;6.23,-42.34,)|

Structure