Reaction Details |
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Target | Tyrosine-protein kinase Fyn |
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Ligand | BDBM50193874 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424212 (CHEMBL908986) |
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IC50 | 23±n/a nM |
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Citation | Noronha, G; Barrett, K; Cao, J; Dneprovskaia, E; Fine, R; Gong, X; Gritzen, C; Hood, J; Kang, X; Klebansky, B; Li, G; Liao, W; Lohse, D; Mak, CC; McPherson, A; Palanki, MS; Pathak, VP; Renick, J; Soll, R; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Zhou, Y Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett16:5546-50 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fyn |
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Name: | Tyrosine-protein kinase Fyn |
Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
Type: | Enzyme |
Mol. Mass.: | 60762.21 |
Organism: | Homo sapiens (Human) |
Description: | P06241 |
Residue: | 537 |
Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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BDBM50193874 |
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n/a |
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Name | BDBM50193874 |
Synonyms: | 7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine | 7-(2,6-dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine | CHEMBL436137 | US8481536, 322 |
Type | Small organic molecule |
Emp. Form. | C28H31N5O |
Mol. Mass. | 453.5786 |
SMILES | Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 |
Structure |
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