| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1/beta-2 |
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| Ligand | BDBM50196392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_420106 (CHEMBL873748) |
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| IC50 | 1000±n/a nM |
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| Citation |  El Abdellaoui, H; Varaprasad, CV; Barawkar, D; Chakravarty, S; Maderna, A; Tam, R; Chen, H; Allan, M; Wu, JZ; Appleby, T; Yan, S; Zhang, W; Lang, S; Yao, N; Hamatake, R; Hong, Z Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett16:5561-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1/beta-2 |
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| Name: | Ribosomal protein S6 kinase beta-1/beta-2 |
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| Synonyms: | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase 1/2 | Ribosomal protein S6 kinase 2/S6K1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 195569 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| Component 2 |
| Name: | Ribosomal protein S6 kinase beta-2 |
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| Synonyms: | KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53460.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306115 |
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| Residue: | 482 |
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| Sequence: | MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
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| Component 3 |
| Name: | Ribosomal protein S6 kinase beta-2 |
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| Synonyms: | KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53460.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306115 |
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| Residue: | 482 |
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| Sequence: | MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
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| BDBM50196392 |
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| n/a |
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| Name | BDBM50196392 |
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| Synonyms: | 3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine | 3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylamino)phenylamino)isothiazole-4-carboximidamide | CHEMBL253116 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O2S |
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| Mol. Mass. | 383.467 |
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| SMILES | CC(CO)N=C(N)c1c(Nc2ccc(Nc3ccccc3)cc2)s[nH]c1=O |w:4.3| |
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| Structure | 
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