| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 1 |
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| Ligand | BDBM50194109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_403341 (CHEMBL868048) |
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| Ki | 37±n/a nM |
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| Citation |  Andersen, TF; Tikhonov, DB; Bølcho, U; Bolshakov, K; Nelson, JK; Pluteanu, F; Mellor, IR; Egebjerg, J; Strømgaard, K Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives. J Med Chem49:5414-23 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 1 |
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| Name: | Glutamate receptor 1 |
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| Synonyms: | AMPA-selective glutamate receptor 1 | GRIA1_RAT | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor ionotropic, AMPA 1 | Gria1 |
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| Type: | Protein |
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| Mol. Mass.: | 101583.91 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19490 |
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| Residue: | 907 |
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| Sequence: | MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGM
PLGATGL
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| BDBM50194109 |
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| n/a |
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| Name | BDBM50194109 |
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| Synonyms: | (S)-N-(1-(5-(8-aminooctylamino)pentylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide | CHEMBL212557 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H46N4O3 |
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| Mol. Mass. | 462.6684 |
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| SMILES | CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCCCN |
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| Structure | 
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