Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50194274 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_393089 (CHEMBL853473) |
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IC50 | 3.9±n/a nM |
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Citation | Neumeyer, JL; Peng, X; Knapp, BI; Bidlack, JM; Lazarus, LH; Salvadori, S; Trapella, C; Balboni, G New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem49:5640-3 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50194274 |
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n/a |
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Name | BDBM50194274 |
Synonyms: | (-)-H-Dmt-Tic-beta-Ala-O-3-hydroxy-N-cyclobutylmethylmorphinan | CHEMBL373984 | MCL-450 |
Type | Small organic molecule |
Emp. Form. | C45H56N4O5 |
Mol. Mass. | 732.9499 |
SMILES | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCC(=O)Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1 |
Structure |
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