Reaction Details |
| Report a problem with these data |
Target | Collagenase 3 |
---|
Ligand | BDBM50194282 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_424283 (CHEMBL908435) |
---|
IC50 | 1±n/a nM |
---|
Citation | Reiter, LA; Freeman-Cook, KD; Jones, CS; Martinelli, GJ; Antipas, AS; Berliner, MA; Datta, K; Downs, JT; Eskra, JD; Forman, MD; Greer, EM; Guzman, R; Hardink, JR; Janat, F; Keene, NF; Laird, ER; Liras, JL; Lopresti-Morrow, LL; Mitchell, PG; Pandit, J; Robertson, D; Sperger, D; Vaughn-Bowser, ML; Waller, DM; Yocum, SA Potent, selective pyrimidinetrione-based inhibitors of MMP-13. Bioorg Med Chem Lett16:5822-6 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Collagenase 3 |
---|
Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
BDBM50194282 |
---|
n/a |
---|
Name | BDBM50194282 |
Synonyms: | 5-(2-ethoxyethyl)-5-(4-(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)phenoxy)phenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | CHEMBL221497 |
Type | Small organic molecule |
Emp. Form. | C27H23N5O7 |
Mol. Mass. | 529.5008 |
SMILES | CCOCCC1(Oc2ccc(Oc3ccc(cc3)-c3nc(no3)-c3ccccn3)cc2)C(=O)NC(=O)NC1=O |
Structure |
|