Reaction Details |
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Target | Collagenase 3 |
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Ligand | BDBM50194294 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424283 (CHEMBL908435) |
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IC50 | 0.85±n/a nM |
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Citation | Reiter, LA; Freeman-Cook, KD; Jones, CS; Martinelli, GJ; Antipas, AS; Berliner, MA; Datta, K; Downs, JT; Eskra, JD; Forman, MD; Greer, EM; Guzman, R; Hardink, JR; Janat, F; Keene, NF; Laird, ER; Liras, JL; Lopresti-Morrow, LL; Mitchell, PG; Pandit, J; Robertson, D; Sperger, D; Vaughn-Bowser, ML; Waller, DM; Yocum, SA Potent, selective pyrimidinetrione-based inhibitors of MMP-13. Bioorg Med Chem Lett16:5822-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Collagenase 3 |
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Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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BDBM50194294 |
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n/a |
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Name | BDBM50194294 |
Synonyms: | CHEMBL221806 | N-(3-fluorobenzyl)-4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyrimidin-5-yloxy)phenoxy)benzamide |
Type | Small organic molecule |
Emp. Form. | C28H26FN3O7 |
Mol. Mass. | 535.5203 |
SMILES | CCOCCC1(Oc2ccc(Oc3ccc(cc3)C(=O)NCc3cccc(F)c3)cc2)C(=O)NC(=O)NC1=O |
Structure |
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