Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50194488 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424403 (CHEMBL911334) |
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Ki | 0.051±n/a nM |
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Citation | Shiotani, K; Li, T; Miyazaki, A; Tsuda, Y; Bryant, SD; Ambo, A; Sasaki, Y; Lazarus, LH; Okada, Y Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. Bioorg Med Chem Lett16:5793-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50194488 |
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n/a |
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Name | BDBM50194488 |
Synonyms: | 6-[4'-(H-Dmt)-aminobutyl]-3-[3'-(H-Dmt)-aminopropyl]-5-methyl-2(1H)-pyrazinone | CHEMBL385779 |
Type | Small organic molecule |
Emp. Form. | C34H48N6O5 |
Mol. Mass. | 620.7821 |
SMILES | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)NCCCCc1[nH]c(=O)c(CCCNC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)nc1C |
Structure |
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