Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM50194671 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_396654 (CHEMBL871547) |
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IC50 | >5000±n/a nM |
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Citation | DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cee, VJ; Chai, L; Deak, HL; Epstein, LF; Faust, T; Gallant, P; Geuns-Meyer, SD; Gore, A; Gu, Y; Henkle, B; Hodous, BL; Hsieh, F; Huang, X; Kim, JL; Lee, JH; Martin, MW; Masse, CE; McGowan, DC; Metz, D; Mohn, D; Morgenstern, KA; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, PE; Schneider, S; Tomlinson, SA; Tudor, YY; Turci, SM; Welcher, AA; White, RD; Zhao, H; Zhu, L; Zhu, X Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem49:5671-86 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM50194671 |
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n/a |
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Name | BDBM50194671 |
Synonyms: | 4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)phenyl)benzamide | CHEMBL386661 |
Type | Small organic molecule |
Emp. Form. | C30H30F3N5O2 |
Mol. Mass. | 549.5867 |
SMILES | CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1OC1CCN(C)CC1)C(F)(F)F |
Structure |
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