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TargetMitogen-activated protein kinase kinase kinase 8
LigandBDBM50194993
Substrate/Competitorn/a
Meas. Tech.ChEMBL_424645 (CHEMBL855706)
IC50 2200±n/a nM
Citation Hu, YGreen, NGavrin, LKJanz, KKaila, NLi, HQThomason, JRCuozzo, JWHall, JPHsu, SNickerson-Nutter, CTelliez, JBLin, LLTam, S Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett16:6067-72 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 8
Name:Mitogen-activated protein kinase kinase kinase 8
Synonyms:C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2
Type:Serine/threonine-protein kinase
Mol. Mass.:52916.89
Organism:Homo sapiens (Human)
Description:P41279
Residue:467
Sequence:
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
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  Blast E-value cutoff:
BDBM50194993
n/a
NameBDBM50194993
Synonyms:4-(3-chloro-4-fluorophenylamino)-6-((tetrahydrofuran-2-yl)methylamino)quinoline-3-carbonitrile | CHEMBL374071
TypeSmall organic molecule
Emp. Form.C21H18ClFN4O
Mol. Mass.396.845
SMILESFc1ccc(Nc2c(cnc3ccc(NCC4CCCO4)cc23)C#N)cc1Cl
Structure
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