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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50195481 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_425005 (CHEMBL912530) | ||
| Ki | 4±n/a nM | ||
| Citation |  Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 31889.48 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P16232 | ||
| Residue: | 288 | ||
| Sequence: |
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| BDBM50195481 | |||
| n/a | |||
| Name | BDBM50195481 | ||
| Synonyms: | (1s,4s)-ethyl 4-(4-amino-3,5-dichloro-N-cyclopropylbenzamido)cyclohexanecarboxylate | CHEMBL376256 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24Cl2N2O3 | ||
| Mol. Mass. | 399.311 | ||
| SMILES | CCOC(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:8.11,5.4,(3.32,-20.85,;4.65,-20.08,;5.98,-20.86,;7.32,-20.09,;8.65,-20.86,;7.32,-18.55,;8.66,-17.78,;8.67,-16.24,;7.33,-15.47,;6,-16.24,;5.99,-17.77,;7.33,-13.93,;6,-13.16,;5.23,-11.83,;4.46,-13.16,;8.67,-13.16,;8.67,-11.62,;10,-13.93,;11.33,-13.16,;12.66,-13.92,;13.99,-13.15,;12.67,-15.47,;14,-16.24,;11.33,-16.25,;11.33,-17.79,;10,-15.47,)| | ||
| Structure | 
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