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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50195506
Substrate/Competitorn/a
Meas. Tech.ChEMBL_425004 (CHEMBL912529)
Ki 4±n/a nM
Citation Richards, SSorensen, BJae, HSWinn, MChen, YWang, JFung, SMonzon, KFrevert, EUJacobson, PSham, HLink, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM50195506
n/a
NameBDBM50195506
Synonyms:(4-amino-3,5-dichloro-phenyl)-(2-aza-tricyclo[3.3.1.1*3,7*]dec-2-yl)-methanone | CHEMBL222938
TypeSmall organic molecule
Emp. Form.C16H18Cl2N2O
Mol. Mass.325.233
SMILESNc1c(Cl)cc(cc1Cl)C(=O)N1C2CC3CC(C2)CC1C3 |TLB:20:19:15.14.13:17,THB:9:11:15.14.13:17,20:14:17:11.18.19,15:14:11:16.17.18,15:16:11:14.13.20|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: