Reaction Details |
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Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
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Ligand | BDBM50195562 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_414256 (CHEMBL908330) |
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IC50 | 17600±n/a nM |
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Citation | Gilbert, AM; Failli, A; Shumsky, J; Yang, Y; Severin, A; Singh, G; Hu, W; Keeney, D; Petersen, PJ; Katz, AH Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase. J Med Chem49:6027-36 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-N-acetylenolpyruvoylglucosamine reductase |
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Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
Synonyms: | MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB |
Type: | Protein |
Mol. Mass.: | 37848.05 |
Organism: | Escherichia coli K-12 (Enterobacteria) |
Description: | E. coli MurB |
Residue: | 342 |
Sequence: | MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
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BDBM50195562 |
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n/a |
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Name | BDBM50195562 |
Synonyms: | 4-[1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1Hpyrazole-4-carbonyl]aminobenzoic acid ethyl ester | CHEMBL217390 |
Type | Small organic molecule |
Emp. Form. | C25H18Cl2N2O5 |
Mol. Mass. | 497.327 |
SMILES | CCOC(=O)c1ccc(cc1)C(=O)c1c(O)n(-c2ccc(Cl)cc2)n(-c2ccc(Cl)cc2)c1=O |
Structure |
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