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TargetUDP-N-acetylenolpyruvoylglucosamine reductase
LigandBDBM50195584
Substrate/Competitorn/a
Meas. Tech.ChEMBL_414256 (CHEMBL908330)
IC50 21900±n/a nM
Citation Gilbert, AMFailli, AShumsky, JYang, YSeverin, ASingh, GHu, WKeeney, DPetersen, PJKatz, AH Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase. J Med Chem49:6027-36 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylenolpyruvoylglucosamine reductase
Name:UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms:MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB
Type:Protein
Mol. Mass.:37848.05
Organism:Escherichia coli K-12 (Enterobacteria)
Description:E. coli MurB
Residue:342
Sequence:
MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50195584
n/a
NameBDBM50195584
Synonyms:1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-hydroxyphenyl)amide | CHEMBL438475
TypeSmall organic molecule
Emp. Form.C22H14Cl2N2O4
Mol. Mass.441.264
SMILESOc1c(C(=O)c2ccc(O)cc2)c(=O)n(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1
Structure
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