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TargetHistone deacetylase 1
LigandBDBM50196593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422105
IC50 22±n/a nM
Citation Marson CMMahadevan TDines JSengmany SMorrell JMAlao JPJoel SPVigushin DMCharles Coombes R Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett 17:136-41 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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  Blast E-value cutoff:
BDBM50196593
n/a
NameBDBM50196593
Synonyms:CHEMBL387042 | N-hydroxy-7-(4-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylamino)phenoxy)heptanamide
TypeSmall organic molecule
Emp. Form.C21H29N3O5
Mol. Mass.403.4721
SMILESCc1ncc(CO)c(CNc2ccc(OCCCCCCC(=O)NO)cc2)c1O
Structure
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