| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50196605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422105 (CHEMBL907102) |
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| IC50 | 13±n/a nM |
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| Citation |  Marson, CM; Mahadevan, T; Dines, J; Sengmany, S; Morrell, JM; Alao, JP; Joel, SP; Vigushin, DM; Charles Coombes, R Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett17:136-41 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50196605 |
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| n/a |
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| Name | BDBM50196605 |
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| Synonyms: | 7-(4-(2-(1H-indol-3-yl)acetamido)phenyl1H-indol-3-yl)acetamido)phenoxy)-N-hydroxyheptanamide | CHEMBL216498 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N3O4 |
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| Mol. Mass. | 409.4782 |
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| SMILES | ONC(=O)CCCCCCOc1ccc(NC(=O)Cc2c[nH]c3ccccc23)cc1 |
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| Structure | 
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