Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHistone deacetylase 1
LigandBDBM50196606
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422105
IC50 24±n/a nM
Citation Marson CMMahadevan TDines JSengmany SMorrell JMAlao JPJoel SPVigushin DMCharles Coombes R Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett 17:136-41 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50196606
n/a
NameBDBM50196606
Synonyms:7-(4-(2-(1H-indol-3-yl)acetamido)-3-fluorophenyl1H-indol-3-yl)acetamido)-3-fluorophenoxy)-N-hydroxyheptanamide | CHEMBL217334
TypeSmall organic molecule
Emp. Form.C23H26FN3O4
Mol. Mass.427.4686
SMILESONC(=O)CCCCCCOc1ccc(NC(=O)Cc2c[nH]c3ccccc23)c(F)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: