Reaction Details | |||
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Target | Protein kinase C theta type | ||
Ligand | BDBM50196957 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453152 (CHEMBL902302) | ||
IC50 | 5±n/a nM | ||
Citation | Cywin, CL; Dahmann, G; Prokopowicz, AS; Young, ER; Magolda, RL; Cardozo, MG; Cogan, DA; Disalvo, D; Ginn, JD; Kashem, MA; Wolak, JP; Homon, CA; Farrell, TM; Grbic, H; Hu, H; Kaplita, PV; Liu, LH; Spero, DM; Jeanfavre, DD; O'Shea, KM; White, DM; Woska, JR; Brown, ML Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett17:225-30 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein kinase C theta type | |||
Name: | Protein kinase C theta type | ||
Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 81878.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
Residue: | 706 | ||
Sequence: |
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BDBM50196957 | |||
n/a | |||
Name | BDBM50196957 | ||
Synonyms: | CHEMBL246175 | N2-(2-bromobenzyl)-N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C19H25BrN6O2 | ||
Mol. Mass. | 449.345 | ||
SMILES | NCC1CCC(CNc2nc(NCc3ccccc3Br)ncc2[N+]([O-])=O)CC1 |(5.93,-24.27,;5.93,-22.73,;4.6,-21.95,;3.26,-22.72,;1.93,-21.95,;1.94,-20.42,;.61,-19.65,;.6,-18.11,;-.73,-17.34,;-2.07,-18.11,;-3.4,-17.34,;-4.74,-18.11,;-6.07,-17.34,;-7.41,-18.11,;-8.74,-17.33,;-10.07,-18.1,;-10.07,-19.64,;-8.73,-20.41,;-7.4,-19.64,;-6.07,-20.41,;-3.4,-15.8,;-2.07,-15.03,;-.74,-15.79,;.6,-15.01,;1.93,-15.78,;.59,-13.47,;3.26,-19.63,;4.6,-20.41,)| | ||
Structure |