Reaction Details | |||
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Target | Protein kinase C theta type | ||
Ligand | BDBM50196982 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_453152 (CHEMBL902302) | ||
IC50 | 29±n/a nM | ||
Citation | Cywin, CL; Dahmann, G; Prokopowicz, AS; Young, ER; Magolda, RL; Cardozo, MG; Cogan, DA; Disalvo, D; Ginn, JD; Kashem, MA; Wolak, JP; Homon, CA; Farrell, TM; Grbic, H; Hu, H; Kaplita, PV; Liu, LH; Spero, DM; Jeanfavre, DD; O'Shea, KM; White, DM; Woska, JR; Brown, ML Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett17:225-30 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein kinase C theta type | |||
Name: | Protein kinase C theta type | ||
Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 81878.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
Residue: | 706 | ||
Sequence: |
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BDBM50196982 | |||
n/a | |||
Name | BDBM50196982 | ||
Synonyms: | CHEMBL395691 | N2-(2-chlorobenzyl)-N4-(((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)-5-nitropyrimidine-2,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C19H25ClN6O2 | ||
Mol. Mass. | 404.894 | ||
SMILES | NC[C@H]1CC[C@H](CNc2nc(NCc3ccccc3Cl)ncc2[N+]([O-])=O)CC1 |wU:5.5,wD:2.1,(19.68,-26.91,;19.68,-25.37,;18.35,-24.6,;18.35,-23.05,;17.02,-22.28,;15.69,-23.06,;14.36,-22.29,;14.35,-20.75,;13.02,-19.98,;11.68,-20.76,;10.35,-19.99,;9.01,-20.75,;7.68,-19.98,;6.35,-20.75,;5.01,-19.98,;3.68,-20.74,;3.68,-22.29,;5.02,-23.06,;6.35,-22.29,;7.68,-23.05,;10.35,-18.44,;11.68,-17.67,;13.01,-18.43,;14.35,-17.66,;15.69,-18.42,;14.34,-16.12,;15.69,-24.59,;17.01,-25.36,)| | ||
Structure |