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TargetNeuropeptide Y receptor type 2
LigandBDBM50197020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_453177 (CHEMBL902327)
Ki 6±n/a nM
Citation DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett17:538-41 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuropeptide Y receptor type 2
Name:Neuropeptide Y receptor type 2
Synonyms:NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:Enzyme Catalytic Domain
Mol. Mass.:42734.65
Organism:Homo sapiens (Human)
Description:NPY-Y2 NPY2R HUMAN::P49146
Residue:381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
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  Blast E-value cutoff:
BDBM50197020
n/a
NameBDBM50197020
Synonyms:(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(4-aminophenyl)formamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-3-carbamoylpropanamido]-4-methylpentanamido]-3-methylbutanamido]-3-hydroxybutanamido]-5-carbamimidamidopentanamido]-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]pentanediamide | CHEMBL397528
TypeSmall organic molecule
Emp. Form.C79H121N27O18
Mol. Mass.1736.9761
SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(N)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:74.76,75.79,4.4,92.94,20.28,59.61,112.114,wD:67.69,8.17,30.39,81.83,51.53,101.103,(11.85,2.11,;11.85,.57,;13.19,-.2,;10.52,-.2,;10.52,-1.74,;9.18,-2.5,;7.85,-1.73,;7.85,-.19,;6.52,-2.5,;6.52,-4.04,;7.85,-4.81,;9.18,-4.04,;10.52,-4.81,;10.52,-6.35,;11.83,-7.11,;9.18,-7.12,;7.85,-6.35,;5.18,-1.73,;3.86,-2.51,;3.86,-4.05,;2.53,-1.74,;2.53,-.2,;3.86,.57,;5.27,-.06,;6.3,1.09,;5.53,2.42,;4.02,2.1,;1.19,-2.5,;-.15,-1.73,;-.15,-.19,;-1.47,-2.5,;-1.47,-4.04,;-.15,-4.81,;-.15,-6.35,;1.19,-7.12,;1.2,-8.66,;-.15,-9.43,;2.51,-9.43,;-2.81,-1.74,;-4.13,-2.53,;-4.13,-4.07,;-5.47,-1.76,;-5.47,-.22,;-6.8,.55,;-8.13,-.22,;-9.47,.55,;-8.13,-1.77,;-6.79,-2.53,;11.85,-2.51,;11.85,-4.05,;13.18,-1.73,;14.51,-2.5,;14.51,-4.04,;15.84,-4.81,;17.17,-4.03,;15.84,-6.35,;15.84,-1.73,;15.84,-.19,;17.18,-2.5,;18.51,-1.73,;18.51,-.19,;19.84,.58,;19.84,2.12,;21.18,-.19,;19.84,-2.5,;19.84,-4.04,;21.17,-1.73,;22.51,-2.5,;22.51,-4.04,;23.83,-4.81,;21.17,-4.81,;23.83,-1.73,;23.83,-.19,;25.17,-2.5,;26.51,-1.73,;26.51,-.19,;25.17,.58,;27.83,.59,;27.83,-2.5,;27.83,-4.04,;29.16,-1.72,;30.49,-2.5,;30.49,-4.04,;31.82,-4.81,;31.82,-6.35,;33.16,-7.11,;33.16,-8.65,;31.82,-9.41,;34.5,-9.41,;31.82,-1.73,;31.82,-.19,;33.16,-2.49,;34.5,-1.73,;34.5,-.19,;35.83,.58,;35.83,2.12,;34.49,2.9,;37.16,2.89,;35.83,-2.5,;35.83,-4.04,;37.16,-1.73,;38.49,-2.5,;38.49,-4.04,;39.82,-4.81,;39.82,-6.35,;41.16,-7.11,;41.16,-8.65,;39.82,-9.42,;42.49,-9.42,;39.82,-1.73,;39.82,-.19,;41.15,-2.5,;42.49,-1.73,;42.49,-.19,;43.82,.58,;45.16,-.19,;46.49,.58,;46.49,2.12,;47.82,2.89,;45.16,2.89,;43.82,2.12,;43.82,-2.5,;45.16,-1.73,;43.82,-4.04,)|
Structure
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