Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 2

Ligand

BDBM50197019

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_453177 (CHEMBL902327)

4±n/a nM

Citation

DeCarr, LB; Buckholz, TM; Coish, PD; Fathi, Z; Fisk, SE; Mays, MR; O'Connor, SJ; Lumb, KJ Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett17:538-41 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 2

Name:

Neuropeptide Y receptor type 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42734.65

Organism:

Homo sapiens (Human)

Description:

NPY-Y2 NPY2R HUMAN::P49146

Residue:

381

Sequence:

MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV

BDBM50197019

n/a

Name

BDBM50197019

Synonyms:

(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(3-aminophenyl)formamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-5-yl)propanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-3-carbamoylpropanamido]-4-methylpentanamido]-3-methylbutanamido]-3-hydroxybutanamido]-5-carbamimidamidopentanamido]-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]pentanediamide | CHEMBL241105

Type

Small organic molecule

Emp. Form.

C79H121N27O18

Mol. Mass.

1736.9761

SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1cccc(N)c1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:74.76,75.79,4.4,92.94,20.28,59.61,112.114,wD:67.69,8.17,30.39,81.83,51.53,101.103,(11.09,-34.41,;11.09,-35.95,;12.43,-36.72,;9.76,-36.72,;9.76,-38.26,;8.42,-39.01,;7.09,-38.24,;7.09,-36.7,;5.76,-39.01,;5.76,-40.55,;7.09,-41.32,;8.42,-40.55,;9.76,-41.32,;9.76,-42.86,;11.07,-43.63,;8.42,-43.63,;7.09,-42.86,;4.42,-38.25,;3.1,-39.03,;3.1,-40.57,;1.77,-38.26,;1.77,-36.72,;3.1,-35.95,;4.5,-36.58,;5.54,-35.43,;4.77,-34.1,;3.26,-34.42,;.43,-39.02,;-.91,-38.25,;-.91,-36.71,;-2.23,-39.02,;-2.23,-40.56,;-.91,-41.33,;-.91,-42.87,;.43,-43.64,;.44,-45.18,;-.91,-45.94,;1.75,-45.94,;-3.57,-38.26,;-4.89,-39.04,;-4.89,-40.58,;-6.23,-38.27,;-6.23,-36.73,;-7.56,-35.97,;-8.89,-36.74,;-8.89,-38.28,;-10.22,-39.06,;-7.55,-39.05,;11.09,-39.03,;11.09,-40.57,;12.42,-38.25,;13.75,-39.02,;13.75,-40.56,;15.08,-41.33,;16.41,-40.55,;15.08,-42.87,;15.08,-38.25,;15.08,-36.71,;16.42,-39.01,;17.75,-38.25,;17.75,-36.71,;19.08,-35.94,;19.08,-34.4,;20.42,-36.71,;19.08,-39.02,;19.08,-40.56,;20.41,-38.24,;21.74,-39.02,;21.74,-40.56,;23.07,-41.33,;20.41,-41.33,;23.07,-38.25,;23.07,-36.71,;24.41,-39.02,;25.74,-38.25,;25.74,-36.71,;24.41,-35.94,;27.07,-35.93,;27.07,-39.02,;27.07,-40.56,;28.4,-38.24,;29.73,-39.01,;29.73,-40.55,;31.06,-41.32,;31.06,-42.86,;32.4,-43.63,;32.4,-45.17,;31.06,-45.93,;33.74,-45.93,;31.06,-38.24,;31.06,-36.7,;32.4,-39.01,;33.74,-38.25,;33.74,-36.71,;35.07,-35.94,;35.07,-34.4,;33.73,-33.62,;36.4,-33.63,;35.07,-39.02,;35.07,-40.56,;36.4,-38.24,;37.73,-39.02,;37.73,-40.56,;39.06,-41.33,;39.06,-42.87,;40.39,-43.63,;40.39,-45.17,;39.06,-45.93,;41.73,-45.93,;39.06,-38.25,;39.06,-36.71,;40.39,-39.01,;41.73,-38.25,;41.73,-36.71,;43.06,-35.94,;44.39,-36.71,;45.73,-35.94,;45.73,-34.4,;47.06,-33.63,;44.39,-33.63,;43.06,-34.4,;43.06,-39.02,;44.39,-38.25,;43.06,-40.56,)|

Structure