Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50197517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_432271 (CHEMBL914049) |
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pH | 7±n/a |
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IC50 | 2.3±n/a nM |
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Comments | extracted |
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Citation | Pryde, DC; Cook, AS; Burring, DJ; Jones, LH; Foll, S; Platts, MY; Sanderson, V; Corless, M; Stobie, A; Middleton, DS; Foster, L; Barker, L; Van Der Graaf, P; Stacey, P; Kohl, C; Coggon, S; Beaumont, K Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Bioorg Med Chem15:142-59 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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BDBM50197517 |
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n/a |
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Name | BDBM50197517 |
Synonyms: | (S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyclopentylmethyl}-4-methoxy-butyric acid | CHEMBL225085 |
Type | Small organic molecule |
Emp. Form. | C21H30ClNO4 |
Mol. Mass. | 395.92 |
SMILES | COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O |
Structure |
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