| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50197978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453299 (CHEMBL902454) |
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| IC50 | 154±n/a nM |
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| Citation |  Pinkerton, AB; Huang, D; Cube, RV; Hutchinson, JH; Struthers, M; Ayala, JM; Vicario, PP; Patel, SR; Wisniewski, T; DeMartino, JA; Vernier, JM Diaryl substituted pyrazoles as potent CCR2 receptor antagonists. Bioorg Med Chem Lett17:807-13 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50197978 |
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| n/a |
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| Name | BDBM50197978 |
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| Synonyms: | 3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-pyrazol-5-yloxy)-N-(1-(diethylamino)heptan-4-yl)propanamide | CHEMBL239143 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40Cl2N4O2 |
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| Mol. Mass. | 595.602 |
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| SMILES | CCCC(CCCN(CC)CC)NC(=O)CCOc1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 |w:3.11| |
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| Structure | 
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