| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50197995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453307 (CHEMBL902462) |
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| IC50 | 63±n/a nM |
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| Citation |  Pinkerton, AB; Huang, D; Cube, RV; Hutchinson, JH; Struthers, M; Ayala, JM; Vicario, PP; Patel, SR; Wisniewski, T; DeMartino, JA; Vernier, JM Diaryl substituted pyrazoles as potent CCR2 receptor antagonists. Bioorg Med Chem Lett17:807-13 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50197995 |
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| n/a |
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| Name | BDBM50197995 |
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| Synonyms: | (S)-2-{4-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-yl]-butyrylamino}-5-guanidino-pentanoic acid methyl ester | CHEMBL241497 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32Cl2N6O3 |
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| Mol. Mass. | 595.519 |
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| SMILES | [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#6]-c1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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