| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50198352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432577 (CHEMBL918283) |
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| Ki | 27500±n/a nM |
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| Citation |  Dixit, M; Tripathi, BK; Tamrakar, AK; Srivastava, AK; Kumar, B; Goel, A Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors. Bioorg Med Chem15:727-34 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50198352 |
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| n/a |
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| Name | BDBM50198352 |
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| Synonyms: | 1-(5-acetyl-6,6'-dihydroxy-2',3'-dihydro-[2,3']-bibenzofuranyl-5'-yl)-ethanone | CHEMBL224735 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14O6 |
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| Mol. Mass. | 350.3216 |
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| SMILES | CC(=O)c1ccc2oc(cc2c1O)-c1coc2ccc(C(C)=O)c(O)c12 |
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| Structure | 
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