| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 5 |
|---|
| Ligand | BDBM50199064 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_411693 (CHEMBL913527) |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Trotter, BW; Nanda, KK; Kett, NR; Regan, CP; Lynch, JJ; Stump, GL; Kiss, L; Wang, J; Spencer, RH; Kane, SA; White, RB; Zhang, R; Anderson, KD; Liverton, NJ; McIntyre, CJ; Beshore, DC; Hartman, GD; Dinsmore, CJ Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. J Med Chem49:6954-7 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily A member 5 |
|---|
| Name: | Potassium voltage-gated channel subfamily A member 5 |
|---|
| Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67222.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22460 |
|---|
| Residue: | 613 |
|---|
| Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
|
|
|
|---|
| BDBM50199064 |
|---|
| n/a |
|---|
| Name | BDBM50199064 |
|---|
| Synonyms: | 2-{3-hydroxy-2-[(pyridin-3-ylmethyl)amino]propyl}-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile | CHEMBL214553 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H24N4O3 |
|---|
| Mol. Mass. | 440.4938 |
|---|
| SMILES | COc1ccc2c(c1)c(-c1ccccc1)c(C#N)n(CC(CO)NCc1cccnc1)c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
