Reaction Details | |||
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Target | Glucagon receptor | ||
Ligand | BDBM50199497 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_441038 (CHEMBL890125) | ||
IC50 | 76.0±n/a nM | ||
Citation | Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett17:587-92 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucagon receptor | |||
Name: | Glucagon receptor | ||
Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 54026.92 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P47871 | ||
Residue: | 477 | ||
Sequence: |
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BDBM50199497 | |||
n/a | |||
Name | BDBM50199497 | ||
Synonyms: | 1-(7-((2H-tetrazol-5-yl)carbamoyl)-3,4-dihydro-2H-chromen-4-yl)-1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL411832 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H34F3N7O4 | ||
Mol. Mass. | 601.62 | ||
SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22.57,-53.2,;22.58,-51.66,;24.12,-51.67,;21.04,-51.66,;22.58,-50.12,;23.92,-49.35,;23.92,-47.81,;22.6,-47.05,;21.25,-47.81,;21.25,-49.35,;22.6,-45.51,;23.93,-44.73,;23.93,-43.18,;25.27,-42.41,;26.61,-43.19,;26.6,-44.74,;27.92,-45.49,;27.93,-47.04,;26.59,-47.81,;25.26,-47.04,;25.27,-45.5,;29.26,-47.8,;29.27,-49.34,;30.6,-47.03,;31.93,-47.8,;32.1,-49.33,;33.61,-49.64,;34.38,-48.31,;33.34,-47.17,;21.27,-44.74,;21.26,-43.2,;19.93,-45.51,;18.6,-44.74,;17.26,-45.51,;15.92,-44.74,;15.93,-43.2,;14.59,-42.43,;14.59,-40.89,;14.58,-39.35,;16.13,-40.88,;13.05,-40.9,;17.25,-42.43,;18.59,-43.19,)| | ||
Structure |