Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Glucagon receptor | ||
Ligand | BDBM50199489 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_441038 (CHEMBL890125) | ||
IC50 | 218±n/a nM | ||
Citation | Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett17:587-92 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucagon receptor | |||
Name: | Glucagon receptor | ||
Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 54026.92 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P47871 | ||
Residue: | 477 | ||
Sequence: |
| ||
BDBM50199489 | |||
n/a | |||
Name | BDBM50199489 | ||
Synonyms: | 3-(4-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)chroman-7-carboxamido)propanoic acid | CHEMBL395759 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H38F3N3O6 | ||
Mol. Mass. | 605.6451 | ||
SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(.09,-52.81,;.1,-51.28,;1.64,-51.28,;-1.44,-51.28,;.1,-49.74,;1.44,-48.97,;1.44,-47.42,;.12,-46.66,;-1.23,-47.43,;-1.23,-48.96,;.12,-45.12,;1.45,-44.34,;1.44,-42.8,;2.79,-42.03,;4.13,-42.81,;4.12,-44.35,;5.44,-45.1,;5.44,-46.65,;4.11,-47.42,;2.78,-46.66,;2.78,-45.12,;6.78,-47.42,;6.78,-48.96,;8.11,-46.65,;9.45,-47.41,;10.78,-46.64,;12.11,-47.41,;13.45,-46.63,;12.12,-48.95,;-1.22,-44.35,;-1.22,-42.81,;-2.55,-45.12,;-3.89,-44.35,;-5.23,-45.13,;-6.56,-44.36,;-6.56,-42.81,;-7.89,-42.04,;-7.89,-40.5,;-7.91,-38.96,;-6.35,-40.5,;-9.43,-40.51,;-5.23,-42.04,;-3.89,-42.8,)| | ||
Structure |