| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Seed linoleate 13S-lipoxygenase-1 |
|---|
| Ligand | BDBM32020 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_432884 (CHEMBL915009) |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Siskou, IC; Rekka, EA; Kourounakis, AP; Chrysselis, MC; Tsiakitzis, K; Kourounakis, PN Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties. Bioorg Med Chem15:951-61 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Seed linoleate 13S-lipoxygenase-1 |
|---|
| Name: | Seed linoleate 13S-lipoxygenase-1 |
|---|
| Synonyms: | 15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 94365.66 |
|---|
| Organism: | Glycine max (soybean) |
|---|
| Description: | n/a |
|---|
| Residue: | 839 |
|---|
| Sequence: | MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGK
DTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQ
GTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEY
DRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYV
PRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLP
RDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIR
GLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQI
NQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWL
LAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINA
LARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHG
VRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDL
KDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGT
PEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQ
AFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
|
|
|
|---|
| BDBM32020 |
|---|
| n/a |
|---|
| Name | BDBM32020 |
|---|
| Synonyms: | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | 4-[4-[3,4-bis(oxidanyl)phenyl]-2,3-dimethyl-butyl]benzene-1,2-diol | BDBM166684 | CHEMBL52 | LOX inhibitor, N/A | MLS000069451 | NORDIHYDROGUAIARETIC ACID | Nordihydroguaiaretic acid (NDGA) | SMR000059049 | US10857082, Compound 2.18 | cid_4534 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22O4 |
|---|
| Mol. Mass. | 302.3649 |
|---|
| SMILES | CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
