Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50118599 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458902 (CHEMBL923873) |
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Ki | 229±n/a nM |
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Citation | Gilbert, KM; Boos, TL; Dersch, CM; Greiner, E; Jacobson, AE; Lewis, D; Matecka, D; Prisinzano, TE; Zhang, Y; Rothman, RB; Rice, KC; Venanzi, CA DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorg Med Chem15:1146-59 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50118599 |
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n/a |
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Name | BDBM50118599 |
Synonyms: | 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(naphthalen-2-ylmethyl)piperidine | 4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-1-naphthalen-2-ylmethyl-piperidine | CHEMBL416409 |
Type | Small organic molecule |
Emp. Form. | C31H31F2NO |
Mol. Mass. | 471.5807 |
SMILES | Fc1ccc(cc1)C(OCCC1CCN(Cc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 |
Structure |
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