Reaction Details |
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Target | Liver carboxylesterase |
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Ligand | BDBM50199883 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_427761 (CHEMBL917586) |
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IC50 | >250000±n/a nM |
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Citation | Birkus, G; Wang, R; Liu, X; Kutty, N; MacArthur, H; Cihlar, T; Gibbs, C; Swaminathan, S; Lee, W; McDermott, M Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. Antimicrob Agents Chemother51:543-50 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Liver carboxylesterase |
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Name: | Liver carboxylesterase |
Synonyms: | Carboxylesterase | EST1_PIG |
Type: | PROTEIN |
Mol. Mass.: | 62009.98 |
Organism: | Sus scrofa |
Description: | ChEMBL_427761 |
Residue: | 566 |
Sequence: | MWLLPLVLTSLASSATWAGQPASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPP
LGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVVEQMTSDLFTNGKERLTLEFSEDCLYL
NIYTPADLTKRGRLPVMVWIHGGGLVLGGAPMYDGVVLAAHENVVVVAIQYRLGIWGFFS
TGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLSPLAKNL
FHRAISESGVALTVALVRKDMKAAAKQIAVLAGCKTTTSAVFVHCLRQKSEDELLDLTLK
MKFLTLDFHGDQRESHPFLPTVVDGVLLPKMPEEILAEKDFNTVPYIVGINKQEFGWLLP
TMMGFPLSEGKLDQKTATSLLWKSYPIANIPEELTPVATDKYLGGTDDPVKKKDLFLDLM
GDVVFGVPSVTVARQHRDAGAPTYMYEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGFPLL
KGDAPEEEVSLSKTVMKFWANFARSGNPNGEGLPHWPMYDQEEGYLQIGVNTQAAKRLKG
EEVAFWNDLLSKEAAKKPPKIKHAEL
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BDBM50199883 |
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n/a |
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Name | BDBM50199883 |
Synonyms: | 3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-isochromen-1-one | 3,4-dichloro-1H-isochromen-1-one | 3,4-dichloroisocoumarin | CHEMBL24983 | cid_1609 |
Type | Small organic molecule |
Emp. Form. | C9H4Cl2O2 |
Mol. Mass. | 215.033 |
SMILES | Clc1oc(=O)c2ccccc2c1Cl |
Structure |
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