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TargetCathepsin A (CTSA)
LigandBDBM50022772
Substrate/Competitorn/a
Meas. Tech.ChEMBL_427758
IC50 10000±n/a nM
Citation Birkus GWang RLiu XKutty NMacArthur HCihlar TGibbs CSwaminathan SLee WMcDermott M Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. Antimicrob Agents Chemother 51:543-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin A (CTSA)
Name:Cathepsin A (CTSA)
Synonyms:Cathepsin A | Lysosomal protective protein
Type:Protein
Mol. Mass.:54465.95
Organism:Homo sapiens (Human)
Description:P10619
Residue:480
Sequence:
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50022772
n/a
NameBDBM50022772
Synonyms:CHEMBL1025 | Diisopropoxyphosphoryl fluoride | Diisopropyl fluorophosphonate | Diisopropyl phosphofluoridate | Diisopropyl phosphorofluoridate | Diisopropylfluorophosphate | Diisopropylfluorophosphoric acid ester | Diisopropylphosphorofluoridate | Fluorodiisopropyl phosphate | ISOFLUROPHATE | Isofluorphate | Isoflurophosphate | Isopropyl fluophosphate | Isopropyl phosphorofluoridate | Neoglaucit | O,O'-Diisopropyl phosphoryl fluoride | bis(propan-2-yl) fluorophosphate | diisopropyl fluorophosphate
TypeSmall organic molecule
Emp. Form.C6H14FO3P
Mol. Mass.184.1457
SMILESCC(C)OP(F)(=O)OC(C)C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: