| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal protective protein |
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| Ligand | BDBM50157741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_427758 (CHEMBL917590) |
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| IC50 | >300000±n/a nM |
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| Citation |  Birkus, G; Wang, R; Liu, X; Kutty, N; MacArthur, H; Cihlar, T; Gibbs, C; Swaminathan, S; Lee, W; McDermott, M Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. Antimicrob Agents Chemother51:543-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal protective protein |
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| Name: | Lysosomal protective protein |
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| Synonyms: | CTSA | Cathepsin A | Cathepsin A (CTSA) | Lysosomal protective protein | PPGB | PPGB_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 54465.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10619 |
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| Residue: | 480 |
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| Sequence: | MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
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| BDBM50157741 |
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| n/a |
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| Name | BDBM50157741 |
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| Synonyms: | CHEMBL374508 | E-64 | E64 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N5O5 |
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| Mol. Mass. | 357.4054 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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