Reaction Details |
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Target | Plasmepsin I |
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Ligand | BDBM50200020 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_422536 (CHEMBL911030) |
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Ki | 81±n/a nM |
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Citation | Dell'Agli, M; Parapini, S; Galli, G; Vaiana, N; Taramelli, D; Sparatore, A; Liu, P; Dunn, BM; Bosisio, E; Romeo, S High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem49:7440-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasmepsin I |
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Name: | Plasmepsin I |
Synonyms: | PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor |
Type: | Enzyme |
Mol. Mass.: | 51463.30 |
Organism: | Plasmodium falciparum |
Description: | n/a |
Residue: | 452 |
Sequence: | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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BDBM50200020 |
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n/a |
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Name | BDBM50200020 |
Synonyms: | (3S,4S)-4-((2S,3S)-2-(4-(4-((4-(6-methoxyquinolin-8-ylamino)-pentyl)carbamoyl)phenoxy)benzamido)-3-methylpentanamido)-3-hydroxy-6-methylheptanoic acid butylamide | CHEMBL376250 |
Type | Small organic molecule |
Emp. Form. | C47H64N6O7 |
Mol. Mass. | 825.0471 |
SMILES | CCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccc(Oc2ccc(cc2)C(=O)NCCCC(C)Nc2cc(OC)cc3cccnc23)cc1)C(C)CC |r| |
Structure |
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