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TargetPlasmepsin I
LigandBDBM50200018
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422536
Ki 1±n/a nM
Citation Dell'Agli MParapini SGalli GVaiana NTaramelli DSparatore ALiu PDunn BMBosisio ERomeo S High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem 49:7440-9 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Plasmepsin I
Name:Plasmepsin I
Synonyms:PFAPG | Plasmepsin 1 | Plasmepsin-1 precursor
Type:Enzyme
Mol. Mass.:51463.30
Organism:Plasmodium falciparum
Description:n/a
Residue:452
Sequence:
MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50200018
n/a
NameBDBM50200018
Synonyms:(3S,4S)-4-((2S,3S)-2-(4-(4-((S)-((S)-1-(1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)carbamoyl)phenoxy)benzamido)-3-methylpentanamido)-3-hydroxy-6-methylheptanoic acid butylamide | CHEMBL216917
TypeSmall organic molecule
Emp. Form.C53H74N8O9
Mol. Mass.967.2029
SMILESCCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccc(Oc2ccc(cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCC(C)Nc2cc(OC)cc3cccnc23)cc1)C(C)CC |r|
Structure
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