| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin II |
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| Ligand | BDBM50200021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422537 (CHEMBL911031) |
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| Ki | 12±n/a nM |
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| Citation |  Dell'Agli, M; Parapini, S; Galli, G; Vaiana, N; Taramelli, D; Sparatore, A; Liu, P; Dunn, BM; Bosisio, E; Romeo, S High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem49:7440-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin II |
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| Name: | Plasmepsin II |
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| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
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| Type: | Enzyme |
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| Mol. Mass.: | 51482.09 |
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| Organism: | Plasmodium falciparum |
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| Description: | P46925 |
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| Residue: | 453 |
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| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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| BDBM50200021 |
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| n/a |
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| Name | BDBM50200021 |
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| Synonyms: | (3S,4S)-4-((2S,3S)-2-(4-(4-((S)-(1-(4-(6-methoxyquinolin-8-ylamino)pentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-phenoxy)benzamido)-3-methylpentanamido)-3-hydroxy-6-methylheptanoic acid butylamide | CHEMBL219025 |
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| Type | Small organic molecule |
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| Emp. Form. | C53H75N7O8 |
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| Mol. Mass. | 938.2047 |
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| SMILES | CCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccc(Oc2ccc(cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCCCC(C)Nc2cc(OC)cc3cccnc23)cc1)C(C)CC |r| |
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| Structure | 
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