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TargetD(4) dopamine receptor
LigandBDBM50200028
Substrate/Competitorn/a
Meas. Tech.ChEMBL_422483 (CHEMBL910435)
Ki 1.3±n/a nM
Citation Patel, MVKolasa, TMortell, KMatulenko, MAHakeem, AARohde, JJNelson, SLCowart, MDNakane, MMiller, LNUchic, METerranova, MAEl-Kouhen, OFDonnelly-Roberts, DLNamovic, MTHollingsworth, PRChang, RMartino, BRWetter, JMMarsh, KCMartin, RDarbyshire, JFGintant, GHsieh, GCMoreland, RBSullivan, JPBrioni, JDStewart, AO Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem49:7450-65 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
D(4) dopamine receptor
Name:D(4) dopamine receptor
Synonyms:D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:Enzyme
Mol. Mass.:48373.19
Organism:Homo sapiens (Human)
Description:P21917
Residue:419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50200028
n/a
NameBDBM50200028
Synonyms:2-methoxy-N-(3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)-benzamide | CHEMBL376092
TypeSmall organic molecule
Emp. Form.C21H26N2O2
Mol. Mass.338.4433
SMILESCOc1ccccc1C1CCN(CNC(=O)c2cccc(C)c2)CC1
Structure
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