| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
|---|
| Ligand | BDBM50200265 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_408429 (CHEMBL908864) |
|---|
| IC50 | 1.9±n/a nM |
|---|
| Citation |  Ulven, T; Receveur, JM; Grimstrup, M; Rist, Ø; Frimurer, TM; Gerlach, LO; Mathiesen, JM; Kostenis, E; Uller, L; Högberg, T Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem49:6638-41 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin D2 receptor 2 |
|---|
| Name: | Prostaglandin D2 receptor 2 |
|---|
| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 43295.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5Y4 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
|
|
|
|---|
| BDBM50200265 |
|---|
| n/a |
|---|
| Name | BDBM50200265 |
|---|
| Synonyms: | 4-bromo-2-[1-(2-bromophenyl)-1H-pyrazole-4-carbonyl]phenoxyacetic acid | CHEMBL384979 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12Br2N2O4 |
|---|
| Mol. Mass. | 480.107 |
|---|
| SMILES | OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1Br |
|---|
| Structure | 
|
|---|
Search and Browse
