| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50200271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_408439 (CHEMBL908265) |
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| IC50 | 3.2±n/a nM |
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| Citation |  Ulven, T; Receveur, JM; Grimstrup, M; Rist, Ø; Frimurer, TM; Gerlach, LO; Mathiesen, JM; Kostenis, E; Uller, L; Högberg, T Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem49:6638-41 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD294 antigen | Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_MOUSE | Ptgdr2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42975.89 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2. |
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| Residue: | 382 |
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| Sequence: | MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRM
RQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFL
LSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIM
CYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRT
GRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNP
LLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIP
QLRPTRLIGWMRRGSAEVPQRV
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| BDBM50200271 |
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| n/a |
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| Name | BDBM50200271 |
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| Synonyms: | 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid | CHEMBL217053 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13BrN2O4 |
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| Mol. Mass. | 401.211 |
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| SMILES | OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1 |
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| Structure | 
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