| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50200634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453774 (CHEMBL885775) |
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| Ki | 8.61±n/a nM |
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| Citation |  Black, LA; Nersesian, DL; Sharma, P; Ku, YY; Bennani, YL; Marsh, KC; Miller, TR; Esbenshade, TA; Hancock, AA; Cowart, M 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. Bioorg Med Chem Lett17:1443-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50200634 |
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| n/a |
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| Name | BDBM50200634 |
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| Synonyms: | (R)-4-(6-(2-(2-ethylpyrrolidin-1-yl)ethyl)naphthalen-2-yl)benzonitrile | CHEMBL246680 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N2 |
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| Mol. Mass. | 354.4873 |
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| SMILES | CC[C@@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N |
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| Structure | 
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