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TargetHistamine H3 receptor
LigandBDBM50200646
Substrate/Competitorn/a
Meas. Tech.ChEMBL_453775 (CHEMBL885776)
Ki 1.96±n/a nM
Citation Black, LANersesian, DLSharma, PKu, YYBennani, YLMarsh, KCMiller, TREsbenshade, TAHancock, AACowart, M 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. Bioorg Med Chem Lett17:1443-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:HH3R | HRH3_RAT | Hrh3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48607.98
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50200646
n/a
NameBDBM50200646
Synonyms:4'-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile | CHEMBL247953
TypeSmall organic molecule
Emp. Form.C21H24N2O
Mol. Mass.320.4281
SMILESC[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(cc1)C#N
Structure
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